Ontology highlight
ABSTRACT:
SUBMITTER: Popelka H
PROVIDER: S-EPMC4835208 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Popelka Hana H Klionsky Daniel J DJ
Autophagy 20150101 12
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). This interaction occurs primarily via a conserved motif termed the LC3-interacting region (LIR), or the Atg8-interacting motif (AIM). The consensus sequence for this motif, [W/F/Y]xx[L/I/V], can be found in many proteins, but only some of them are physiological partners containing a functional LIR/AIM. Bec ...[more]