Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.
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ABSTRACT:
SUBMITTER: Weichert S
PROVIDER: S-EPMC4836343 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.
Weichert Stefan S Koromyslova Anna A Singh Bishal K BK Hansman Satoko S Jennewein Stefan S Schroten Horst H Hansman Grant S GS
Journal of virology 20160414 9
Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL and 3FL structurally mimic HBGAs. These results suggest that 2'FL and 3FL might act as naturally occurr ...[more]
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