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Norovirus devours human milk oligosaccharides rich in ?-fucose.

ABSTRACT: Human norovirus binding to histo-blood group antigens (HBGAs) is thought to direct their entry into host cells. However, the glycan epitopes characteristic of HBGAs are also present on oligosaccharides abundant in human milk. In this issue of JBC, Hanisch et al compared norovirus binding to human gastric mucins and human milk oligosaccharides, finding those bound most avidly are rich in ?-fucose. Mimicry of these epitopes with ?-fucose multivalently displayed on other carbohydrate scaffolds successfully scavenged this prevalent virus, providing new insights into norovirus biology and clues for future therapeutic development.

SUBMITTER: Krammer EM 

PROVIDER: S-EPMC6066310 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Norovirus devours human milk oligosaccharides rich in α-fucose.

Krammer Eva-Maria EM   Bouckaert Julie Maria Jozefa JMJ  

The Journal of biological chemistry 20180701 30

Human norovirus binding to histo-blood group antigens (HBGAs) is thought to direct their entry into host cells. However, the glycan epitopes characteristic of HBGAs are also present on oligosaccharides abundant in human milk. In this issue of JBC, Hanisch <i>et al</i> compared norovirus binding to human gastric mucins and human milk oligosaccharides, finding those bound most avidly are rich in α-fucose. Mimicry of these epitopes with α-fucose multivalently displayed on other carbohydrate scaffol  ...[more]

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