Ontology highlight
ABSTRACT:
SUBMITTER: Sorenson MR
PROVIDER: S-EPMC4841608 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sorenson Matthew R MR Jha Deepak K DK Ucles Stefanie A SA Flood Danielle M DM Strahl Brian D BD Stevens Scott W SW Kress Tracy L TL
RNA biology 20160129 4
Co-transcriptional splicing takes place in the context of a highly dynamic chromatin architecture, yet the role of chromatin restructuring in coordinating transcription with RNA splicing has not been fully resolved. To further define the contribution of histone modifications to pre-mRNA splicing in Saccharomyces cerevisiae, we probed a library of histone point mutants using a reporter to monitor pre-mRNA splicing. We found that mutation of H3 lysine 36 (H3K36) - a residue methylated by Set2 duri ...[more]