Ontology highlight
ABSTRACT:
SUBMITTER: Haribhai D
PROVIDER: S-EPMC4851766 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Haribhai Dipica D Ziegelbauer Jennifer J Jia Shuang S Upchurch Kyle K Yan Ke K Schmitt Erica G EG Salzman Nita H NH Simpson Pippa P Hessner Martin J MJ Chatila Talal A TA Williams Calvin B CB
Journal of immunology (Baltimore, Md. : 1950) 20160229 8
Induced regulatory T (iTreg) and Th17 cells promote mucosal homeostasis. We used a T cell transfer model of colitis to compare the capacity of iTreg and Th17 cells to develop in situ following the transfer of naive CD4(+)CD45RB(hi)T cells intoRag1(-/-)C57BL/6 or BALB/c mice, the prototypical Th1/M1- and Th2/M2-prone strains. We found that the frequency and number of Foxp3(+)iTreg cells and Th17 cells were significantly reduced in C57BL/6 mice compared with the BALB/c strain. C57BL/6 mice with co ...[more]