Ontology highlight
ABSTRACT:
SUBMITTER: Jensen L
PROVIDER: S-EPMC4852332 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Jensen L L Jørgensen L H LH Bech R D RD Frandsen U U Schrøder H D HD
BioMed research international 20160418
Muscle weakness is considered the pivotal sign of amyotrophic lateral sclerosis (ALS). Knowledge about the skeletal muscle degeneration/regeneration process and the myogenic potential is limited in ALS patients. Therefore, we investigate these processes in a time course perspective by analysing skeletal muscle biopsies from ALS patients collected before and after a 12-week period of normal daily activities and compare these with healthy age-matched control tissue. We do this by evaluating mRNA a ...[more]