Ontology highlight
ABSTRACT:
SUBMITTER: Payne RO
PROVIDER: S-EPMC4857475 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Payne Ruth O RO Milne Kathryn H KH Elias Sean C SC Edwards Nick J NJ Douglas Alexander D AD Brown Rebecca E RE Silk Sarah E SE Biswas Sumi S Miura Kazutoyo K Roberts Rachel R Rampling Thomas W TW Venkatraman Navin N Hodgson Susanne H SH Labbé Geneviève M GM Halstead Fenella D FD Poulton Ian D ID Nugent Fay L FL de Graaf Hans H Sukhtankar Priya P Williams Nicola C NC Ockenhouse Christian F CF Kathcart April K AK Qabar Aziz N AN Waters Norman C NC Soisson Lorraine A LA Birkett Ashley J AJ Cooke Graham S GS Faust Saul N SN Woods Colleen C Ivinson Karen K McCarthy James S JS Diggs Carter L CL Vekemans Johan J Long Carole A CA Hill Adrian V S AV Lawrie Alison M AM Dutta Sheetij S Draper Simon J SJ
The Journal of infectious diseases 20160204 11
<h4>Background</h4>Models of controlled human malaria infection (CHMI) initiated by mosquito bite have been widely used to assess efficacy of preerythrocytic vaccine candidates in small proof-of-concept phase 2a clinical trials. Efficacy testing of blood-stage malaria parasite vaccines, however, has generally relied on larger-scale phase 2b field trials in malaria-endemic populations. We report the use of a blood-stage P. falciparum CHMI model to assess blood-stage vaccine candidates, using thei ...[more]