Ontology highlight
ABSTRACT:
SUBMITTER: Cash JN
PROVIDER: S-EPMC4860252 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Cash Jennifer N JN Davis Ellen M EM Tesmer John J G JJG
Structure (London, England : 1993) 20160414 5
Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine nucleotide exchange factor synergistically activated by PIP3 and Gβγ that plays an important role in the metastasis of breast, prostate, and skin cancer, making it an attractive therapeutic target. However, the molecular mechanisms behind P-Rex1 regulation are poorly understood. We determined structures of the P-Rex1 pleckstrin homology (PH) domain bound to the headgroup of PIP3 and resolved that ...[more]