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Novel immunotherapeutic approaches to the treatment of urothelial carcinoma.
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ABSTRACT:
SUBMITTER: Muthigi A
PROVIDER: S-EPMC4872187 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Novel immunotherapeutic approaches to the treatment of urothelial carcinoma.
Therapeutic advances in urology 20160209 3
Immunotherapy has long played a role in urothelial cancers with the use of bacille Calmette Guérin (BCG) being a mainstay in the treatment of nonmuscle invasive bladder cancer. Novel therapeutic approaches have not significantly impacted mortality in this population and so a renaissance in immunotherapy has resulted. This includes recombinant BCG, oncolytic viruses, monoclonal antibodies, vaccines, and adoptive T-cell therapy. Herein, we provide a review of the current state of the art and futur ...[more]