Ontology highlight
ABSTRACT:
SUBMITTER: Longo V
PROVIDER: S-EPMC5464921 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Longo Vito V Gnoni Antonio A Casadei Gardini Andrea A Pisconti Salvatore S Licchetta Antonella A Scartozzi Mario M Memeo Riccardo R Palmieri Vincenzo Ostilio VO Aprile Giuseppe G Santini Daniele D Nardulli Patrizia P Silvestris Nicola N Brunetti Oronzo O
Oncotarget 20170501 20
Hepatocellular carcinoma (HCC) is a cancer with a high mortality rate due to the fact that the diagnosis usually occurs at anadvanced stage. Even in case of curative surgical treatment, recurrence is common. Sorafenib and regorafenib are the only therapeutic agents that have been demonstrated to be effective in advanced HCC, thus novel curative approaches are urgently needed. Recent studies focus on the role of immune system in HCC. In fact, the unique immune response in the liver favors toleran ...[more]