Ontology highlight
ABSTRACT:
SUBMITTER: Fujiwara K
PROVIDER: S-EPMC4872455 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Fujiwara K K Fujita Y Y Kasai A A Onaka Y Y Hashimoto H H Okada H H Yamashita T T
Translational psychiatry 20160329
JMJD2B is a histone demethylase enzyme that regulates gene expression through demethylation of H3K9me3. Although mutations of JMJD2B have been suggested to be responsible for neurodevelopmental disorders, the function of JMJD2B in the central nervous system (CNS) remains to be elucidated. Here we show that JMJD2B has a critical role in the development of the CNS. We observed JMJD2B expression, which was especially strong in the hippocampus, throughout the CNS from embryonic periods through adult ...[more]