Ontology highlight
ABSTRACT:
SUBMITTER: Morin-Poulard I
PROVIDER: S-EPMC4874035 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Morin-Poulard Ismaël I Sharma Anurag A Louradour Isabelle I Vanzo Nathalie N Vincent Alain A Crozatier Michèle M
Nature communications 20160519
Self-renewal and differentiation of mammalian haematopoietic stem cells (HSCs) are controlled by a specialized microenvironment called 'the niche'. In the bone marrow, HSCs receive signals from both the endosteal and vascular niches. The posterior signalling centre (PSC) of the larval Drosophila haematopoietic organ, the lymph gland, regulates blood cell differentiation under normal conditions and also plays a key role in controlling haematopoiesis under immune challenge. Here we report that the ...[more]