Ontology highlight
ABSTRACT:
SUBMITTER: Beck MR
PROVIDER: S-EPMC4876643 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Beck Moriah R MR Dekoster Gregory T GT Cistola David P DP Goldman William E WE
Molecular microbiology 20090303 2
The fungal protein CBP (calcium binding protein) is a known virulence factor with an unknown virulence mechanism. The protein was identified based on its ability to bind calcium and its prevalence as Histoplasma capsulatum's most abundant secreted protein. However, CBP has no sequence homology with other CBPs and contains no known calcium binding motifs. Here, the NMR structure of CBP reveals a highly intertwined homodimer and represents the first atomic level NMR model of any fungal virulence f ...[more]