Ontology highlight
ABSTRACT:
SUBMITTER: Melnyk JE
PROVIDER: S-EPMC4878121 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Melnyk James E JE Mohanan Vishnu V Schaefer Amy K AK Hou Ching-Wen CW Grimes Catherine Leimkuhler CL
Journal of the American Chemical Society 20150602 22
Natural modifications of peptidoglycan modulate the innate immune response. Peptidoglycan derivatives activate this response via the intracellular innate immune receptor, Nod2. To probe how these modifications alter the response, a novel and efficient carbohydrate synthesis was developed to allow for late-stage modification of the amine at the 2-position. Modification of the carbohydrate was found to be important for stabilizing Nod2 and generating the proper response. The native Nod2 ligands de ...[more]