Onivyde for the therapy of multiple solid tumors.
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ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC4881920 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Drug delivery system based on nanobiotechnology can improve the pharmacokinetics and therapeutic index of chemotherapeutic agents, which has revolutionized tumor therapy. Onivyde, also known as MM-398 or PEP02, is a nanoliposomal formulation of irinotecan which has demonstrated encouraging anticancer activity across a broad range of malignancies, including pancreatic cancer, esophago-gastric cancer, and colorectal cancer. This up-to-date review not only focuses on the structure, pharmacokinetics ...[more]
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