Ontology highlight
ABSTRACT:
SUBMITTER: Pettit GR
PROVIDER: S-EPMC3616417 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Pettit George R GR Tang Yuping Y Zhang Qingwen Q Bourne Gregory T GT Arm Christoph A CA Leet John E JE Knight John C JC Pettit Robin K RK Chapuis Jean-Charles JC Doubek Dennis L DL Ward Franklin J FJ Weber Christine C Hooper John N A JN
Journal of natural products 20130214 3
An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents subsequently led to the isolation of three new pyrimidine diterpenes designated axistatins 1 (1), 2 (2), and 3 (3), together with the previously reported formamides 4, 5, and agelasine F (6). The structures were elucidated by analysis of 2D-NMR spectra and by HRMS. All of the isolated compounds were found to be moderate inhibitors of cancer cell g ...[more]