A Tubular Biomaterial Construct Exhibiting a Negative Poisson's Ratio.

ABSTRACT: Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson's ratio ?xy (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson's ratios of -0.6 ? ?xy ? -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive ?xy. Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.

SUBMITTER: Lee JW 

PROVIDER: S-EPMC4883790 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature