Ontology highlight
ABSTRACT:
SUBMITTER: Dominguez R
PROVIDER: S-EPMC4884163 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Trends in biochemical sciences 20160405 6
Two types of sequences, proline-rich domains (PRDs) and the WASP-homology 2 (WH2) domain, are found in most actin filament nucleation and elongation factors discovered thus far. PRDs serve as a platform for protein-protein interactions, often mediating the binding of profilin-actin. The WH2 domain is an abundant actin monomer-binding motif comprising ∼17 amino acids. It frequently occurs in tandem repeats, and functions in nucleation by recruiting actin subunits to form the polymerization nucleu ...[more]