Ontology highlight
ABSTRACT:
SUBMITTER: Gould CJ
PROVIDER: S-EPMC3058777 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Gould Christopher J CJ Maiti Sankar S Michelot Alphée A Graziano Brian R BR Blanchoin Laurent L Goode Bruce L BL
Current biology : CB 20110217 5
Formins are a large family of actin assembly-promoting proteins with many important biological roles. However, it has remained unclear how formins nucleate actin polymerization. All other nucleators are known to recruit actin monomers as a central part of their mechanisms. However, the actin-nucleating FH2 domain of formins lacks appreciable affinity for monomeric actin. Here, we found that yeast and mammalian formins bind actin monomers but that this activity requires their C-terminal DAD domai ...[more]