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Folic acid conjugated ferritins as photosensitizer carriers for photodynamic therapy.

ABSTRACT: We coupled folic acid as a tumour targeting ligand to the surface of ferritins and loaded them with ZnF16Pc. The resulting nanoconjugates can efficiently hone in on 4T1 tumours in vivo, and, with photoirradiation, leading to suppressed tumour growth and tumour metastasis.

SUBMITTER: Zhen Z 

PROVIDER: S-EPMC4885642 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Folic acid conjugated ferritins as photosensitizer carriers for photodynamic therapy.

Zhen Zipeng Z   Tang Wei W   Zhang Weizhong W   Xie Jin J  

Nanoscale 20150601 23

We coupled folic acid as a tumour targeting ligand to the surface of ferritins and loaded them with ZnF16Pc. The resulting nanoconjugates can efficiently hone in on 4T1 tumours in vivo, and, with photoirradiation, leading to suppressed tumour growth and tumour metastasis. ...[more]

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