Ontology highlight
ABSTRACT:
SUBMITTER: Jang B
PROVIDER: S-EPMC3287428 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Theranostics 20120211 2
We report on the development of photosensitizer-conjugated gold nanorods (MMP2P-GNR) in which photosensitizers were conjugated onto the surface of gold nanorods (GNR) via a protease-cleavable peptide linker. We hypothesized that fluorescence and phototoxicity of the conjugated photosensitizers would be suppressed in their native state, becoming activated only after cleavage by the target protease matrix metalloprotease-2 (MMP2). Quantitative analysis of the fluorescence and singlet oxygen genera ...[more]