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Palladium-Catalyzed Selective ?-Alkenylation of Pyridylmethyl Ethers with Vinyl Bromides.

ABSTRACT: An efficient palladium-catalyzed ?-alkenylation of pyridylmethyl ethers with vinyl bromides is presented. A Pd/NIXANTPHOS-based catalyst system enables a mild and chemoselective coupling between a variety of pyridylmethyl ethers and vinyl bromides in good to excellent yields. Under the mild conditions, ?,?-unsaturated products are obtained without isomerization or Heck byproducts observed.

SUBMITTER: Yang X 

PROVIDER: S-EPMC4887130 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Palladium-Catalyzed Selective α-Alkenylation of Pyridylmethyl Ethers with Vinyl Bromides.

Yang Xiaodong X   Kim Byeong-Seon BS   Li Minyan M   Walsh Patrick J PJ  

Organic letters 20160510 10

An efficient palladium-catalyzed α-alkenylation of pyridylmethyl ethers with vinyl bromides is presented. A Pd/NIXANTPHOS-based catalyst system enables a mild and chemoselective coupling between a variety of pyridylmethyl ethers and vinyl bromides in good to excellent yields. Under the mild conditions, β,γ-unsaturated products are obtained without isomerization or Heck byproducts observed. ...[more]

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