Ontology highlight
ABSTRACT:
SUBMITTER: Ablajan K
PROVIDER: S-EPMC5722243 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Advanced synthesis & catalysis 20170523 11
The direct arylation of weakly acidic sp<sup>3</sup>-hybridized C-H bonds via deprotonated cross-coupling processes (DCCP) is a challenge. Herein, a Pd(NIXANTPHOS)-based catalyst for the mono arylation of 4-pyridylmethyl 2-aryl ethers to generate diarylated 4-pyridyl methyl ethers is introduced. Furthermore, under similar conditions, the diarylation of 4-pyridylmethyl ethers with aryl bromides has been developed. These methods enable the synthesis of new pyridine derivatives, which are common in ...[more]