Ontology highlight
ABSTRACT:
SUBMITTER: Matsuda K
PROVIDER: S-EPMC4887162 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Matsuda Kenta K Chen Chia-Yen CY Whitted Sonya S Chertova Elena E Roser David J DJ Wu Fan F Plishka Ronald J RJ Ourmanov Ilnour I Buckler-White Alicia A Lifson Jeffrey D JD Strebel Klaus K Hirsch Vanessa M VM
The Journal of clinical investigation 20160509 6
Current antiretroviral therapy (ART) is not sufficient to completely suppress disease progression in the CNS, as indicated by the rising incidence of HIV-1-associated neurocognitive disorders (HAND) among infected individuals on ART. It is not clear why some HIV-1-infected patients develop HAND, despite effective repression of viral replication in the circulation. SIV-infected nonhuman primate models are widely used to dissect the mechanisms of viral pathogenesis in the CNS. Here, we identified ...[more]