Ontology highlight
ABSTRACT:
SUBMITTER: Staprans SI
PROVIDER: S-EPMC516468 | biostudies-literature | 2004 Aug
REPOSITORIES: biostudies-literature
Staprans Silvija I SI Barry Ashley P AP Silvestri Guido G Safrit Jeffrey T JT Kozyr Natalia N Sumpter Beth B Nguyen Hanh H McClure Harold H Montefiori David D Cohen Jeffrey I JI Feinberg Mark B MB
Proceedings of the National Academy of Sciences of the United States of America 20040823 35
Given the dual role of CD4 T cells as both immune effectors and targets for HIV infection, the balance of CD4 versus CD8 T cell-mediated responses induced by candidate AIDS vaccines may be critical in determining postvaccination infection outcomes. An attenuated recombinant varicella-zoster virus vaccine expressing the simian immunodeficiency virus (SIV) envelope (Env) elicited nonneutralizing Env-binding antibodies and little if any cytotoxic T lymphocyte responses in rhesus macaques (Macaca mu ...[more]