Ontology highlight
ABSTRACT:
SUBMITTER: Patel PR
PROVIDER: S-EPMC4887403 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Patel Paresma R PR Sun Wei W Kim Myunghoon M Huang Xiuli X Sanderson Philip E PE Tanaka Takeshi Q TQ McKew John C JC Simeonov Anton A Williamson Kim C KC Zheng Wei W Huang Wenwei W
Bioorganic & medicinal chemistry letters 20160419 12
Novel imidazo[4,5-c]quinolin-2-ones were synthesized and evaluated in asexual blood stage and late stage gametocyte assays of Plasmodium falciparum, a major causative agent of malaria. The design of these compounds is based on a recently identified lead compound from a high throughput screen. A concise synthesis was developed that allowed for generation of analogues with substitution around both the quinoline and imidazolidinone rings. Through structure-activity relationship studies, a number of ...[more]