Ontology highlight
ABSTRACT:
SUBMITTER: Khandelwal NK
PROVIDER: S-EPMC4888455 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Khandelwal Nitesh Kumar NK Kaemmer Philipp P Förster Toni M TM Singh Ashutosh A Coste Alix T AT Andes David R DR Hube Bernhard B Sanglard Dominique D Chauhan Neeraj N Kaur Rupinder R d'Enfert Christophe C Mondal Alok Kumar AK Prasad Rajendra R
The Biochemical journal 20160329 11
Among the several mechanisms that contribute to MDR (multidrug resistance), the overexpression of drug-efflux pumps belonging to the ABC (ATP-binding cassette) superfamily is the most frequent cause of resistance to antifungal agents. The multidrug transporter proteins Cdr1p and Cdr2p of the ABCG subfamily are major players in the development of MDR in Candida albicans Because several genes coding for ABC proteins exist in the genome of C. albicans, but only Cdr1p and Cdr2p have established role ...[more]