Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.
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ABSTRACT:
SUBMITTER: Skvortsova YV
PROVIDER: S-EPMC4889060 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Intragenic Locus in Human PIWIL2 Gene Shares Promoter and Enhancer Functions.
Skvortsova Yulia V YV Kondratieva Sofia A SA Zinovyeva Marina V MV Nikolaev Lev G LG Azhikina Tatyana L TL Gainetdinov Ildar V IV
PloS one 20160601 6
Recently, more evidence supporting common nature of promoters and enhancers has been accumulated. In this work, we present data on chromatin modifications and non-polyadenylated transcription characteristic for enhancers as well as results of in vitro luciferase reporter assays suggesting that PIWIL2 alternative promoter in exon 7 also functions as an enhancer for gene PHYHIP located 60Kb upstream. This finding of an intragenic enhancer serving as a promoter for a shorter protein isoform implies ...[more]
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