Unknown

Dataset Information

0

The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma.


ABSTRACT: CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible for tumorigenic activity, but it is not known how CD90+ cells contribute to tumor initiation and progression. Our data demonstrated that high expression of CD90 in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration in HCC patients. CD90+ cells isolated from HCC cell lines exhibited increased tumorigenicity, chemoresistance, tumor invasion and metastasis. Notch pathway was activated in CD90+ cells and we found that inhibition of Notch pathway in CD90+ CSCs decreased tumorigenicity, cell invasion, migration and expression of stem cell related genes. Activation of Notch pathway in CD90- cells induced self-renewal, invasion and migration. Furthermore, we observed that cancer stem cell features were facilitated by stimulating G1-S transition in the cell cycle phase and inhibiting apoptosis mediated by Notch pathway. Our findings suggested CD90 could be used as a potential biomarker for HCC CSCs, and that cancer stem cell activity was elevated through up activated Notch pathway in CD90+ CSCs.

SUBMITTER: Luo J 

PROVIDER: S-EPMC4891057 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Notch pathway promotes the cancer stem cell characteristics of CD90+ cells in hepatocellular carcinoma.

Luo Jing J   Wang Peng P   Wang Ronghua R   Wang Jinlin J   Liu Man M   Xiong Si S   Li Yawen Y   Cheng Bin B  

Oncotarget 20160201 8


CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible for tumorigenic activity, but it is not known how CD90+ cells contribute to tumor initiation and progression. Our data demonstrated that high expression of CD90 in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration in HCC patients. CD90+ cells isolated from HCC cell lines exhibited increased tumorigenicity, chemoresistance, tumor invasion and metastasis. Notch pathway was activated  ...[more]

Similar Datasets

| S-EPMC8506556 | biostudies-literature
| S-EPMC7180389 | biostudies-literature
| S-EPMC7744694 | biostudies-literature
| S-EPMC5790077 | biostudies-literature
| S-EPMC5532790 | biostudies-literature
| S-EPMC7210388 | biostudies-literature
| S-EPMC4466639 | biostudies-literature
| S-EPMC5835697 | biostudies-literature
| S-EPMC5053705 | biostudies-literature
| S-EPMC10520132 | biostudies-literature