Ontology highlight
ABSTRACT:
SUBMITTER: Luo J
PROVIDER: S-EPMC4891057 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Luo Jing J Wang Peng P Wang Ronghua R Wang Jinlin J Liu Man M Xiong Si S Li Yawen Y Cheng Bin B
Oncotarget 20160201 8
CD90 has been identified as a marker for liver cancer stem cells (CSCs) that are responsible for tumorigenic activity, but it is not known how CD90+ cells contribute to tumor initiation and progression. Our data demonstrated that high expression of CD90 in Hepatocellular Carcinoma (HCC) tissues correlated with venous filtration in HCC patients. CD90+ cells isolated from HCC cell lines exhibited increased tumorigenicity, chemoresistance, tumor invasion and metastasis. Notch pathway was activated ...[more]