Ontology highlight
ABSTRACT:
SUBMITTER: Tomalin LE
PROVIDER: S-EPMC4891068 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Tomalin Lewis Elwood LE Day Alison Michelle AM Underwood Zoe Elizabeth ZE Smith Graham Robert GR Dalle Pezze Piero P Rallis Charalampos C Patel Waseema W Dickinson Bryan Craig BC Bähler Jürg J Brewer Thomas Francis TF Chang Christopher Joh-Leung CJ Shanley Daryl Pierson DP Veal Elizabeth Ann EA
Free radical biology & medicine 20160302
Reactive oxygen species, such as H2O2, can damage cells but also promote fundamental processes, including growth, differentiation and migration. The mechanisms allowing cells to differentially respond to toxic or signaling H2O2 levels are poorly defined. Here we reveal that increasing external H2O2 produces a bi-phasic response in intracellular H2O2. Peroxiredoxins (Prx) are abundant peroxidases which protect against genome instability, ageing and cancer. We have developed a dynamic model simula ...[more]