Natriuretic Peptides and Cardiometabolic Health.
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ABSTRACT:
SUBMITTER: Gupta DK
PROVIDER: S-EPMC4893202 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Natriuretic Peptides and Cardiometabolic Health.
Gupta Deepak K DK Wang Thomas J TJ
Circulation journal : official journal of the Japanese Circulation Society 20150623 8
Natriuretic peptides are cardiac-derived hormones with a range of protective functions, including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved insulin sensitivity. Their actions are mediated through membrane-bound guanylyl cyclases that lead to production of the intracellular second-messenger cyclic guanosine monophosphate. A growing body of evidence demonstrates that genetic and acquired deficiencies of the natriuretic peptide system can promote hypertens ...[more]
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