Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-? Production.
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ABSTRACT:
SUBMITTER: Zhan Y
PROVIDER: S-EPMC4893968 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Publications
Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production.
Zhan Yu Y Seregin Sergey S SS Chen Jiachen J Chen Grace Y GY
Journal of immunology (Baltimore, Md. : 1950) 20160506 12
Chronic intestinal inflammation is a major risk factor for the development of colorectal cancer. Nod1, a member of the Nod-like receptor (NLR) family of pattern recognition receptors, is a bacterial sensor that has been previously demonstrated to reduce susceptibility of mice to chemically induced colitis and subsequent tumorigenesis, but the mechanism by which it mediates its protection has not been elucidated. In this study, we show that Nod1 expression in the hematopoietic cell compartment is ...[more]
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