Ontology highlight
ABSTRACT:
SUBMITTER: Bastos-Aristizabal S
PROVIDER: S-EPMC4894388 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Bastos-Aristizabal Sara S Kozlov Guennadi G Gehring Kalle K
Scientific reports 20140325
Protein Disulfide Isomerase-Like protein of the Testis (PDILT) is a testis-specific member of the PDI family. PDILT displays similar domain architecture to PDIA1, the founding member of this protein family, but lacks catalytic cysteines needed for oxidoreduction reactions. This suggests special importance of chaperone activity of PDILT, but how it recognizes misfolded protein substrates is unknown. Here, we report the high-resolution crystal structure of the b' domain of human PDILT. The structu ...[more]