Ontology highlight
ABSTRACT:
SUBMITTER: Morrow JJ
PROVIDER: S-EPMC4894524 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Morrow James J JJ Khanna Chand C
Critical reviews in oncogenesis 20150101 3-4
Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the g ...[more]