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Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies.

ABSTRACT: Although a de novo clinical presentation of small cell neuroendocrine carcinoma of the prostate is rare, a subset of patients previously diagnosed with prostate adenocarcinoma may develop neuroendocrine features in later stages of castration-resistant prostate cancer (CRPC) progression as a result of treatment resistance. Despite sharing clinical, histologic, and some molecular features with other neuroendocrine carcinomas, including small cell lung cancer, castration-resistant neuroendocrine prostate cancer (CRPC-NE) is clonally derived from prostate adenocarcinoma. CRPC-NE therefore retains early prostate cancer genomic alterations and acquires new molecular changes making them resistant to traditional CRPC therapies. This review focuses on recent advances in our understanding of CRPC-NE biology, the transdifferentiation/plasticity process, and development and characterization of relevant CRPC-NE preclinical models.

SUBMITTER: Puca L

PROVIDER: S-EPMC6360865 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Neuroendocrine Differentiation in Prostate Cancer: Emerging Biology, Models, and Therapies.

Puca Loredana L Vlachostergios Panagiotis J PJ Beltran Himisha H

Cold Spring Harbor perspectives in medicine 20190201 2

Although a de novo clinical presentation of small cell neuroendocrine carcinoma of the prostate is rare, a subset of patients previously diagnosed with prostate adenocarcinoma may develop neuroendocrine features in later stages of castration-resistant prostate cancer (CRPC) progression as a result of treatment resistance. Despite sharing clinical, histologic, and some molecular features with other neuroendocrine carcinomas, including small cell lung cancer, castration-resistant neuroendocrine pr ...[more]

PMID: 29844220

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