Ontology highlight
ABSTRACT:
SUBMITTER: Marchand L
PROVIDER: S-EPMC4895032 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Marchand Lucien L Jalabert Audrey A Meugnier Emmanuelle E Van den Hende Kathleen K Fabien Nicole N Nicolino Marc M Madec Anne-Marie AM Thivolet Charles C Rome Sophie S
Journal of diabetes research 20160524
Background. The use of miRNAs as biomarkers for Type 1 Diabetes (T1D) risk is attractive as T1D is usually diagnosed in front of acute symptoms. As miR-375 is highly expressed in the endocrine pancreas, we postulated that its circulating level might reflect beta cell alterations and might be altered in the blood of T1D patients recently diagnosed. Methods. Sera were obtained from 22 T1D children at onset of the disease, before subcutaneous insulin treatment, and from 10 nondiabetic pediatric con ...[more]