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Copper-mediated arylation with arylboronic acids: Facile and modular synthesis of triarylmethanes.

ABSTRACT: A facile and modular synthesis of triarylmethanes was achieved in good yield via a two-step sequence in which the final step is the copper(II)-catalyzed arylation of diarylmethanols with arylboronic acids. By using this protocol a variety of symmetrical and unsymmetrical triarylmethanes were synthesized. As an application of the newly developed methodology, we demonstrate a high-yielding synthesis of the triarylmethane intermediate towards an anti-breast-cancer drug candidate.

SUBMITTER: Rao HS

PROVIDER: S-EPMC4902010 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Copper-mediated arylation with arylboronic acids: Facile and modular synthesis of triarylmethanes.

Rao H Surya Prakash HS Rao A Veera Bhadra AV

Beilstein journal of organic chemistry 20160311

A facile and modular synthesis of triarylmethanes was achieved in good yield via a two-step sequence in which the final step is the copper(II)-catalyzed arylation of diarylmethanols with arylboronic acids. By using this protocol a variety of symmetrical and unsymmetrical triarylmethanes were synthesized. As an application of the newly developed methodology, we demonstrate a high-yielding synthesis of the triarylmethane intermediate towards an anti-breast-cancer drug candidate. ...[more]

PMID: 27340442

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