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Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes.

ABSTRACT: A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [11C]perampanel in 10% nondecay-corrected radiochemical yield (RCY).

SUBMITTER: Makaravage KJ

PROVIDER: S-EPMC5892454 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes.

Makaravage Katarina J KJ Shao Xia X Brooks Allen F AF Yang Lingyun L Sanford Melanie S MS Scott Peter J H PJH

Organic letters 20180227 6

A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [11C]perampanel in 10% nondecay-corrected radiochemical yield (RCY). ...[more]

PMID: 29484880

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