Copper(II)-Mediated [11C]Cyanation of Arylboronic Acids and Arylstannanes.
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ABSTRACT: A copper-mediated method for the transformation of diverse arylboron compounds and arylstannanes to aryl-[11C]-nitriles is reported. This method is operationally simple, uses commercially available reagents, and is compatible with a wide variety of substituted aryl- and heteroaryl substrates. This method is applied to the automated synthesis of high specific activity [11C]perampanel in 10% nondecay-corrected radiochemical yield (RCY).
SUBMITTER: Makaravage KJ
PROVIDER: S-EPMC5892454 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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