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Asymmetric ?-amination of 3-substituted oxindoles using chiral bifunctional phosphine catalysts.

ABSTRACT: A highly enantioselective ?-amination of 3-substituted oxindoles with azodicarboxylates catalyzed by amino acids-derived chiral phosphine catalysts is reported. The corresponding products containing a tetrasubstituted carbon center attached to a nitrogen atom at the C-3 position of the oxindole were obtained in high yields and with up to 98% ee.

SUBMITTER: Jin QW

PROVIDER: S-EPMC4902028 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Asymmetric α-amination of 3-substituted oxindoles using chiral bifunctional phosphine catalysts.

Jin Qiao-Wen QW Chai Zhuo Z Huang You-Ming YM Zou Gang G Zhao Gang G

Beilstein journal of organic chemistry 20160415

A highly enantioselective α-amination of 3-substituted oxindoles with azodicarboxylates catalyzed by amino acids-derived chiral phosphine catalysts is reported. The corresponding products containing a tetrasubstituted carbon center attached to a nitrogen atom at the C-3 position of the oxindole were obtained in high yields and with up to 98% ee. ...[more]

PMID: 27340464

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