Ontology highlight
ABSTRACT:
SUBMITTER: Benavent L
PROVIDER: S-EPMC6099788 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Molecules (Basel, Switzerland) 20180606 6
The use of readily available chiral <i>trans</i>-cyclohexanediamine-benzimidazole derivatives as bifunctional organocatalysts in the asymmetric electrophilic amination of unprotected 3-substituted oxindoles is presented. Different organocatalysts were evaluated; the most successful one contained a dimethylamino moiety (<b>5</b>). With this catalyst under optimized conditions, different oxindoles containing a wide variety of substituents at the 3-position were aminated in good yields and with goo ...[more]