HIV-1 Vpu Mediates HLA-C Downregulation.
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ABSTRACT:
SUBMITTER: Apps R
PROVIDER: S-EPMC4904791 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
HIV-1 Vpu Mediates HLA-C Downregulation.
Apps Richard R Del Prete Gregory Q GQ Chatterjee Pramita P Lara Abigail A Brumme Zabrina L ZL Brockman Mark A MA Neil Stuart S Pickering Suzanne S Schneider Douglas K DK Piechocka-Trocha Alicja A Walker Bruce D BD Thomas Rasmi R Shaw George M GM Hahn Beatrice H BH Keele Brandon F BF Lifson Jeffrey D JD Carrington Mary M
Cell host & microbe 20160501 5
Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis. HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-mediated downregulation of HLA-A and -B but not HLA-C molecules. We find that HLA-C is downregulated by most primary HIV-1 clones, including transmitted founder viruses, in contrast to the laboratory-adapted NL4-3 virus. HLA-C reduction is mediated by viral Vpu and ...[more]
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