PTP1B: mediating ROS signaling to silence genes.
Ontology highlight
ABSTRACT:
SUBMITTER: Boivin B
PROVIDER: S-EPMC4905060 | biostudies-literature | 2015 Apr-Jun
REPOSITORIES: biostudies-literature
Publications
PTP1B: mediating ROS signaling to silence genes.
Boivin Benoit B Tonks Nicholas K NK
Molecular & cellular oncology 20150226 2
Numerous studies have shown that normal cells often respond to the activation of oncogenes by undergoing reactive oxygen species-dependent induction of senescence. Here, we discuss our recent publication identifying protein tyrosine phosphatase PTP1B as an important redox-controlled checkpoint for senescence downstream of oncogenic RAS. ...[more]
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