Ontology highlight
ABSTRACT:
SUBMITTER: Lv YC
PROVIDER: S-EPMC4905646 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Lv Yun-Cheng YC Tang Yan-Yan YY Zhang Ping P Wan Wei W Yao Feng F He Ping-Ping PP Xie Wei W Mo Zhong-Cheng ZC Shi Jin-Feng JF Wu Jian-Feng JF Peng Juan J Liu Dan D Cayabyab Francisco S FS Zheng Xi-Long XL Tang Xiang-Yang XY Ouyang Xin-Ping XP Tang Chao-Ke CK
PloS one 20160613 6
ATP-binding cassette transporter A1 (ABCA1) plays a critical role in maintaining cellular cholesterol homeostasis. The purpose of this study is to identify the molecular mechanism(s) underlying ABCA1 epigenetic modification and determine its potential impact on ABCA1 expression in macrophage-derived foam cell formation and atherosclerosis development. DNA methylation induced foam cell formation from macrophages and promoted atherosclerosis in apolipoprotein E-deficient (apoE-/-) mice. Bioinforma ...[more]