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A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.

ABSTRACT: A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.

SUBMITTER: Poh JS

PROVIDER: S-EPMC4906367 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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A multistep continuous flow synthesis machine for the preparation of pyrazoles <i>via</i> a metal-free amine-redox process.

Poh Jian-Siang JS Browne Duncan L DL Ley Steven V SV

Reaction chemistry & engineering 20160107 1

A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target. ...[more]

PMID: 27398231

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