Ontology highlight
ABSTRACT:
SUBMITTER: Britton J
PROVIDER: S-EPMC6990874 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20170620 30
A rapid and modular continuous flow synthesis of highly functionalized fluorinated pyrazoles and pyrazolines has been developed. Flowing fluorinated amines through sequential reactor coils mediates diazoalkane formation and [3+2] cycloaddition to generate more than 30 azoles in a telescoped fashion. Pyrazole cores are then sequentially modified through additional reactor modules performing N-alkylation and arylation, deprotection, and amidation to install broad molecular diversity in short order ...[more]