Ontology highlight
ABSTRACT:
SUBMITTER: Ehsan M
PROVIDER: S-EPMC4906958 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Ehsan Muhammad M Du Yang Y Scull Nicola J NJ Tikhonova Elena E Tarrasch Jeffrey J Mortensen Jonas S JS Loland Claus J CJ Skiniotis Georgios G Guan Lan L Byrne Bernadette B Kobilka Brian K BK Chae Pil Seok PS
Journal of the American Chemical Society 20160311 11
Detergents are essential tools for membrane protein manipulation. Micelles formed by detergent molecules have the ability to encapsulate the hydrophobic domains of membrane proteins. The resulting protein-detergent complexes (PDCs) are compatible with the polar environments of aqueous media, making structural and functional analysis feasible. Although a number of novel agents have been developed to overcome the limitations of conventional detergents, most have traditional head groups such as glu ...[more]