Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC4908399 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Liu Shuang S Sahid Muhammad Novrizal Abdi MN Takemasa Erika E Kiyoi Takeshi T Kuno Miyuki M Oshima Yusuke Y Maeyama Kazutaka K
Scientific reports 20160615
Ca(2+) release-activated calcium channel 3 (CRACM3) is a unique member of the CRAC family of Ca(2+)-selective channels. In a non-excitable exocytosis model, we found that the extracellular L3 domain and the cytoplasmic C-terminus of CRACM3 interacted in an activity-dependent manner with the N-peptide of syntaxin4, a soluble N-ethylmaleimide-sensitive factor attachment receptor protein. Our biochemical, electrophysiological and single-vesicle studies showed that knockdown of CRACM3 suppressed fun ...[more]