Ontology highlight
ABSTRACT:
SUBMITTER: Theodoratou E
PROVIDER: S-EPMC4908421 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Theodoratou Evropi E Thaçi Kujtim K Agakov Felix F Timofeeva Maria N MN Štambuk Jerko J Pučić-Baković Maja M Vučković Frano F Orchard Peter P Agakova Anna A Din Farhat V N FV Brown Ewan E Rudd Pauline M PM Farrington Susan M SM Dunlop Malcolm G MG Campbell Harry H Lauc Gordan G
Scientific reports 20160615
In this study we demonstrate the potential value of Immunoglobulin G (IgG) glycosylation as a novel prognostic biomarker of colorectal cancer (CRC). We analysed plasma IgG glycans in 1229 CRC patients and correlated with survival outcomes. We assessed the predictive value of clinical algorithms and compared this to algorithms that also included glycan predictors. Decreased galactosylation, decreased sialylation (of fucosylated IgG glycan structures) and increased bisecting GlcNAc in IgG glycan s ...[more]