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Recent advances in understanding and treating vasculitis.

ABSTRACT: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the treatment landscape of AAV. Questions, nevertheless, remain regarding the appropriate timing, dose, frequency, duration, and long-term effects of treatment. The aim of this article is to provide an overview of the current information, recent advances, ongoing clinical trials, and future treatment possibilities in AAV.

SUBMITTER: Koster MJ

PROVIDER: S-EPMC4916989 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Recent advances in understanding and treating vasculitis.

Koster Matthew J MJ Warrington Kenneth J KJ

F1000Research 20160620

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the treatment landscape of AAV. Questions, nevertheless, remain regarding the appropriate timing, dos ...[more]

PMID: 27347395

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Dataset Information

Recent advances in understanding and treating vasculitis.

Publications

Recent advances in understanding and treating vasculitis.

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