Temporal and Triggered Evolution of Host-Guest Characteristics in Amphiphilic Polymer Assemblies.

ABSTRACT: An amphiphilic polymer with cleavable side chain and main chain functional groups has been designed and synthesized. Specific cleavage of either of its functional groups was found to have an effect on the morphology of the assembly. Degradation of the main chain is shown to cause morphology of the supramolecular assembly to evolve with time from a micelle-like assembly to a vesicular assembly. On the other hand, stimulus-induced cleavage of the side chains causes these nanoassemblies to disassemble. These temporal (main chain) and triggered (side chain) degradation processes have implications in the design of degradable polymers as supramolecular scaffolds for biological applications.

SUBMITTER: Rangadurai P 

PROVIDER: S-EPMC4917414 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature